Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation

Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation

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Objective: It is unclear why specific individuals incur chronic symptoms following a concussion.This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS).Methods: Fifteen adults with PCS and 13 healthy, non-injured adults were tourettebrewing.com tested.All participants completed symptom questionnaires, and transcranial magnetic stimulation (TMS) was used to measure intracortical and transcallosal excitability and inhibition in the dominant motor cortex.

Results: Cortical silent period (p = 0.02, g = 0.96) and ipsilateral silent period (p = 0.04, g = 0.

78) were shorter in the PCS group compared to the control group which may reflect reduced GABA-mediated inhibition in PCS.Furthermore, increased corticomotor excitability was observed in the left hemisphere but not the right hemisphere.Conclusions: These data suggest that persistent neurophysiological differences are present in those with PCS.The exact contributing factors to such changes remain to read more be investigated by future studies.

Significance: This study provides novel evidence of lasting neurophysiological changes in PCS.